These viruses may not be apocalyptic, but if one gets them, their life is about to get really bad, really fast. The main inspiration for 28 Days Later 's Rage Virus is the Ebola Virus, a fairly rare condition, but that's somewhat infamous due to its horrifying side effects.
Once contracted, Ebola hits the sufferer with fever, pain, diarrhea, and eventually uncontrollable levels of bleeding both internally and externally. It can cause one's organs to shut down as well, leading, obviously, to a very uncomfortable demise. Like the Rage Virus, Ebola is passed through contact with infected blood, and can be passed among all primates, such as between chimps and people.
Part of the reason director Danny Boyle and screenwriter Alex Garland chose to go with infected people instead of traditional zombies was the idea that one of mankind's greatest fears in the current age is getting a deadly disease or contracting some kind of plague. In addition to Ebola, the Marburg virus helped inspire Rage, which was actually used as an apocalyptic plague on the Chris Carter TV series Millennium.
Humanity's fear of an apocalyptic outbreak is still clearly present today, nearly 20 years after 28 Days Later was written, as evidenced by the paranoia surrounding the spread of the Corona Virus in China. From them, the Rage Virus began to spread throughout the island of Great Britain.
The Rage Virus causes its hosts to permanently enter a primal state of murderous rage with a biological imperative to spread the infection or kill the uninfected above all else. The infected are reduced to an animalistic state of permanent hostility and aggression, driving them to attack non-infected with no concern for their own safety and no moral or other inhibitions that could control their actions and behaviour.
As strange as it is, it is not responsible for biological death of its host, nor would it be the direct cause of death. In this state of permanent and extreme psychosis, much similar to the puberty cycle the brain is undergoing continuous hormonal changes. One of these changes includes continuously pumping adrenaline into the host's system, giving the Infected odd feats of strength, agility, endurance especially in pursuit of the uninfected. However this hormonal distribution places enormous stress on their metabolism.
The infected sprinters act with no regard for self preservation and will not act to evade mortal danger. Due to the lack in self preservation sprinters often become disinterested in self nourishment, this will eventually lead to physical exhaustion, coma, and lastly death caused by starvation.
The virus enters the circulatory system and is quick to manifest itself into the victim, causing symptoms within hours and full infiltration within a 24 hour period.
As the virus infiltrates the host, they experience a spasmodic effect. Shaking and or shuddering of the outer extremities in a rapid manner. Following that seizures and frothing of the mouth will occur as symptoms progress.
Copious amounts of infected blood is continually gibbered out of the mouth area because of deliquescent organs. Depending on how much infected blood and saliva entered the wound, could potentially change the time of infiltration.
The virus passes through bodily fluids. Some people may possess a hereditary immunity, allowing them to become infected with the virus without exhibiting any of its usual symptoms. These people would remain carriers of the infection, and can transmit it through blood-saliva contact and saliva exchange. In the film 28 Weeks Later it is shown that there are certain people who, while not immune to the virus in the truest sense, can carry the virus without any physical or psychological changes, except for one - a reddening of parts of the left eye.
These people are classified as "asymptomatic carriers" possibly a mistake by the scientists in the film, as the eye change is technically a symptom. A carrier will not become uncontrollably violent like other infected and will otherwise be unaffected by the presence of the virus. A carrier can, of course, still spread the virus as they still carry it in their blood and saliva. The audience is led to believe that whatever traits the carrier's biology uses to resist the full effects of the virus may be harnessed to develop a cure or vaccine.
After they successfully developed an inhibitor, Warren believed that delivering widespread with a pill or an aerosol wouldn't do, and decided to use the Ebola Virus as a delivery system. However, within two weeks, several isolated genomes in the Ebola Virus reacted to the inhibitor and mutated, causing the inhibitor to have the opposite effect - instead of inhibiting anger, it caused its hosts to become full of constant, uncontrollable rage - and creating the Rage Virus.
After the Rage Virus developed, Clive quit from the project and informed the Animal Freedom Front about the experimentation on animals out of disgust at what he and Warren had created. That chimpanzee attacked and infected one of the activists, who then infected a scientist and the other activists. From them, the Rage Virus spread throughout Great Britain.
The streets of London are attacked by the Infected. After the release of the infected chimps from the Cambridge Primate Research Centre , the Rage Virus began to spread throughout Cambridge and eventually the whole of Great Britain.
At first, the effects of the Virus were regarded by the media as rioting, 28 Days Later film , 28 Days Later: The Aftermath but they were discredited by the public, as the Infected were attacking small villages and market towns as well as cities such as London and Cambridge. Eight days after Infection was released, the Prime Minister declared a state of emergency and martial law was imposed.
However, the military blockades protecting London and Manchester were overrun by the Infected, causing the remainder of the panicked public that was not already infected to try and evacuate the country. Within the next thirteen days, British society broke down and Great Britain was overrun by the Infected and destroyed by the Rage Virus. Apart from the few scattered survivors, the rest of the British population were either dead, infected, or had escaped during the exodus.
After the Original Outbreak, the original Infected gradually began to die from starvation. An Infected starving to death sixty days after Infection was released. At some point a matter of months after the Original Outbreak, the Rage Virus spread from mainland Britain to Shetland ; the island was secretly quarantined by the American military, and the Infection seemed to overrun Shetland. After most of the Infected died, the US Army began to repopulate London on the Isle of Dogs , while their forces decontaminated the rest of the city.
However, twenty-eight weeks after the Original Outbreak, Alice Harris , an asymptomatic carrier of the Rage Virus, was brought into the safe zone, District One. Alice reunited with her husband, Don , but unknowingly infected him with Rage through a kiss. After killing Alice, the infected Don went on a rampage in District One, infecting or killing anyone he came across and igniting an outbreak of the Rage Virus in the Green Zone.
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